Dichloromethane mutagenicity

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August undefined, 2024

WebDichloromethane (DCM) is a colorless liquid with a sweet, pleasant odor. The major use of DCM is as a solvent in the pharmaceutical and chemical industry for reactions, purification and isolation of intermediates or products. WebMutagenicity is an important toxicological endpoint that requires thorough evaluation during the industrial chemical registration process. Regulatory requirements for mutagenicity assessment in registration of industrial chemicals vary in geographic regions (and in some cases by intended application). ... Methanol (90%) and dichloromethane ...

Human Health Effects of Dichloromethane: Key Findings …

WebDichloromethane is no longer produced in Canada (CPI, 2000). From 1977 to 1990, the quantity of dichloromethane imported and used in Canada ranged annually from 9 to 13.2 kilotonnes (Environment Canada, 1990); however, usage of pure dichloromethane, recycled dichloromethane and dichloromethane contained in formulations has … WebNov 28, 2016 · 1,2-Dichloropropane (1,2-DCP) and dichloromethane (DCM) are possible causative agents associated with the development of cholangiocarcinoma in employees … folding flatbed hand cart

MATERIAL SAFETY DATA SHEET - Smart Lab

WebGerm cell mutagenicity Ames test S. typhimurium Result: negative Mutagenicity (micronucleus test) Hamster - male and female Result: negative Carcinogenicity IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC. Reproductive toxicity No … WebProduct name : Dichloromethane CAS-No. : 75-09-2 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratory chemicals, Industrial & for professional use only. 1.3 Details of the supplier of the safety data sheet Company : Central Drug House (P) Ltd 7/28 Vardaan House New Delhi-10002 folding flatbed cart fpc330

Influence of GSH S-transferase on the mutagenicity induced by ...

GreenScreen Assessment for Dichloromethane (DCM) (CAS …

WebBiodegradation of dichloromethane (DCM) to environmentally acceptable products was demonstrated under methanogenic conditions (35 degrees C). When DCM was supplied … Web1,2-Dichloropropane (1,2-DCP) and dichloromethane (DCM) are possible causative agents associated with the development of cholangiocarcinoma in employees working in printing plant in Osaka, Japan. However, few reports have demonstrated an association between these agents and cholangiocarcinoma in rod … egr cleaner kitWebDichloromethane is a lipophilic solvent of low relative molecular mass, which can readily cross biological membranes. Pulmonary uptake is rapid, approaching steady state within … folding flat bed sheets

"Hepatic toxicity. Hepatic effects are commonly observed forms of toxicity following inhalation (Burek et al. 1984; Nitschke et al. 1988) or oral (Serota et al. 1986a) dichloromethane exposure in rodents. Changes observed in animals following dichloromethane exposure include liver foci/areas of alteration, … See more In 2011, the Integrated Risk Information System (IRIS) of the U.S. Environmental Protection Agency (EPA) released an updated Toxicological Review of Dichloromethane (Methylene Chloride) (U.S. EPA 2011). In … See more The toxicological review was developed according to the general risk assessment guidelines (National Research Council 1983, 1994). The literature search strategy was based on the … See more In summary, the IRIS Toxicological Review of Dichloromethane (U.S. EPA 2011) developed noncancer reference dose values for oral … See more Dichloromethane metabolism occurs primarily in the liver but also in lung tissues, particularly in mice. The PBPK model structure for dichloromethane traces back to one … See more " - Dichloromethane mutagenicity

Dichloromethane mutagenicity

Material Safety Data Sheet - Washington State University

WebJan 1, 1978 · The possible mutagenicity of the organic solvent dichloromethane was investigated with the mutation test as described by Ames et al. The compound was … WebThe mutagenicity of dichloromethane was evaluated in Salmonella bacterial tester strains TA98, TA100, TA1535, TA1537, and TA1538 and Saccharomyces cerevisiae yeast …

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WebMay 17, 2024 · It has been suggested that dichloromethane (DCM) and 1,2-dichloropropane (DCP) are responsible for occupational cholangiocarcinoma. Dihaloalkanes are ... Osamu Endo, Kazuho Inaba, Yukari Totsuka, Influence of GSH S-transferase on the mutagenicity induced by dichloromethane and 1,2-dichloropropane, Mutagenesis, … WebMay 4, 2024 · Mulaudzi et al. evaluated the cytotoxicity activities of petroleum ether, dichloromethane, ethanol and water extracts of S. cordatum by evaluating the mutagenicity using the Salmonella /microsome assay using the plate-incorporation procedure with Salmonella typhimurium tester strains TA98, TA100 and TA102 with and …

WebDichloromethane, Methylene dichloride CAS No. 75-09-2 RTECS No. PA8050000. DOT ID & Guide. 1593 160. Formula. CH₂Cl₂ ... WebEnzyme-mediated dichloromethane toxicity and mutagenicity of bacterial and mammalian dichloromethane-active glutathione S-transferases Daniel Gisi, Thomas Leisinger & …

WebAgency for Toxic Substances and Disease Registry WebThe dichloromethane extracts of SRM 1649 and SRM 1650 contained direct-acting mutagens in Salmonella strains TA98 and TA100; SRM 1650 was significantly more potent than SRM 1649 in either strain. Addition of S9 caused a large decrease in mutagenicity of each extract, although SRM 1650 remained more potent.

WebJul 1, 2024 · It has been suggested that dichloromethane (DCM) and 1,2-dichloropropane (DCP) are responsible for occupational cholangiocarcinoma. Dihaloalkanes are metabolically activated by GSH S-transferase theta1 (GSTT1) to yield products such as episulfonium ions. However, whether the GSTT1-mediated step of t …

WebSix chicken-essence concentrates (CEC) or their dichloromethane extracts (DECE) showed inhibition of the mutagenicity of indirect environmental mutagens such as 2-amino-3-methylimidazo[4,5- f]quinoline (IQ), 3-amino-l-methyl-5-H-pyrido[4,3-b] indole (Trp-P-2), and benzo[a]pyrene (B[a)P), but contrarily had no effect on direct environmental ... folding flags for shadow boxesWebMutagenicity: DNA inhibition: Human, Fibroblast = 5000 ppm/1H (Continuous).; Morphological transformation: Rat, Embryo = 160 umol/L.; DNA damage: Oral, rat = 1275 mg/kg.; ... The neurotoxicity is thought to be due to a direct nonspecific CNS depressant action of dichloromethane and to indirect effects of carbon monoxide. … egr cooler 60 burstWebfor mutagenicity of a cosmetic substance to be annexed in the Regulation (EC) No 1223/2009 should include tests to provide information on the three genotoxic endpoints, namely 1) mutagenicity at the gene level, 2) chromosome breakage and/or rearrangements (clastogenicity), and 3) numerical chromosome aberrations (aneuploidy). This egr cleaning solutions montgomery countyWebDichloromethane was originally selected for substance evaluation in order to clarify concerns about: - Carcinogenic - Suspected mutagenic - Suspected reprotoxic - … folding flat chair coversWebIn vivo mutagenicity was analyzed by gpt mutation/Spi-assays in the livers of rats. In addition, gene and protein expression of CYP2E1 and GSTT1, the major enzymes … egr cleaning brisbaneWebAbstract. Dichloromethane (DCM) or methylene chloride is a volatile, colorless liquid with a chloroform-like odor. When methyl chloride or methane reacts with chlorine gas at very … egr chrome bug shieldWebProduct name : Dichloromethane Product Number : 270997 Brand : Sigma-Aldrich Supplier : Sigma-Aldrich 3050 Spruce Street SAINT LOUIS MO 63103 USA Telephone : +1 800-325-5832 ... Germ cell mutagenicity Genotoxicity in vivo - rat - Oral DNA damage Carcinogenicity Carcinogenicity - rat - Inhalation Tumorigenic:Carcinogenic by RTECS … egr cleaner spray diesel