WebHere we discovered that AIM2 regulated the innate immune sensors Pyrin and ZBP1 to drive inflammatory signaling and inflammatory cell death, PANoptosis, and provide host … WebMay 13, 2024 · Moreover, DHA inhibited the invasion and migration of A431 cells. Mechanistically, DHA promoted autophagy and inhibited activation of the absent in melanoma 2 (AIM2) inflammasome pathway and NF-κB/HIF-1α/VEGF pathway. Treatment of A431 cells with the mTOR inhibitor, and autophagy promoter, rapamycin also inhibited …
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WebApr 15, 2024 · Gastric cancer (GC) is the third leading cause of cancer-related mortality worldwide, and poses a great threat to public health. Absent in melanoma 2 (AIM2), a member of the pyrin-HIN family ... WebAssembly of an inflammasome complex requires cytosolic sensing of pathogen-associated molecular patterns or danger-associated molecular patterns by a nucleotide-binding … how many newtons are in a kg
Scientists find key function of molecule in cells crucial for ...
WebApr 9, 2024 · Because AIM2 does not discriminate between host and microbial dsDNA, it is widely believed that activation of AIM2 inflammasome underlies the pathogenesis of many auto-inflammatory diseases (Kumari et al., 2024).In support of this notion, AIM2, along with other inflammasome components, has been shown to play a pathogenic role in various … WebThis opens a wide range of opportunities: discover them with Aim2. OUR TECHNOLOGY. Deep Learning. Efficient, reliable and optimized Deep Learning models that can run together on a single machine device. Computer vision. Technology that helps to solve “visual problems” avoiding human intervention and simplifying user’s life. WebNov 11, 2016 · AIM2 is an innate immune sensor that mediates assembly and activation of inflammasome in response to double-stranded DNA (dsDNA) (9, 10).We found that AIM2-deficient mice were protected from SBI-induced lethality and intestinal damage ().In accordance with previous observations (11–13), WT mice exhibited severe loss of crypts … how many newtons are there in 5mn