Cisplatin pten
WebObjective: Resistance to cisplatin-centered chemotherapy is a major cause of treatment failure in human ovarian cancer. Whereas PTEN, a tumor suppressor gene product, is believed to promote apoptosis primarily via inactivation of the PI3K/Akt cell survival pathway, recent evidence suggests that PTEN may function independently of this pathway. WebPTEN is a tumor-suppressor gene deactivating PI3K downstream of EGFR signaling. We hypothesize that PTEN-deficient lung cancer cells suppressed DNA damage signaling and that the absence of PTEN can sensitize these cells to a concurrent treatment of a DNA-damaging agent (cisplatin) and a PARP inhibitor (olaparib).
Cisplatin pten
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WebSep 28, 2007 · We report that EF24, a synthetic compound 3,5-bis (2-flurobenzylidene)piperidin-4-one, greatly inhibits cisplatin-resistant (CR) human ovarian cancer cell proliferation. The inhibitory effect of EF24 on cell proliferation is associated with G (2)/M phase cell cycle arrest and increased G (2)/M checkpoint protein (pp53, p53, … WebCisplatin / pharmacology Cyclin-Dependent Kinase Inhibitor p27 / metabolism Drug Synergism Female Gene Expression Regulation, Neoplastic / drug effects Humans Intracellular Signaling Peptides and Proteins / antagonists & inhibitors Intracellular Signaling Peptides and Proteins / genetics* Intracellular Signaling Peptides and Proteins / …
WebSep 24, 2024 · The main lipid substrate of PTEN is PIP 3 and indeed PTEN acts as a negative regulator of PI3K/AKT signaling. ... Wu, D. M. et al. The PAX6-ZEB2 axis promotes metastasis and cisplatin resistance ... WebConclusion: TGF-β induced TMEPAI contributes to the reduced response of TNBC treatment to doxorubicin and paclitaxel, but minimal on cisplatin and bicalutamide. Further study is needed to confirm our findings in other growth factor-induced cells, as well as in in vivo model. Keywords: TMEPAI, TGF-β, doxorubicin, paclitaxel.
WebJun 7, 2024 · The PTEN gene was hypothesized to be regulated by miRNA-21 in ovarian cancer cisplatin resistance. Materials and methods Cell lines and cell culture The SKOV3 human ovarian cancer cell line was purchased from Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (Shanghai, China).
WebNov 19, 2024 · Cisplatin is an anti-cancer chemotherapy drug which used to treat ovarian cancer in women who have already received surgery and/or radiation treatment. However, either resistance to cisplatin or multi-drug resistance (MDR) to cisplatin-centered chemotherapy is a major cause of treatment failure in human ovarian cancer.
WebJul 26, 2013 · In the cytoplasm, PTEN antagonizes the phosphatidylinositol 3-kinase (PI3K) signaling pathway. PTEN also accumulates in the nucleus, where its function remains poorly understood. We demonstrate that SUMOylation (SUMO, small ubiquitin-like modifier) of PTEN controls its nuclear localization. can amlodipine make you pee moreWebMay 10, 2013 · Cisplatin treatment promotes phosphorylation of AKT. PTEN is known as a negative regulator of AKT phosphorylation. The phosphorylation of AKT was analyzed … canam manac lavalWebSpiral ganglion neurons (SGNs) are auditory neurons that relay sound signals from the inner ear to the brainstem. The ototoxic drug cisplatin can damage SGNs and thus lead to sensorineural hearing loss (SNHL), and there are currently no methods for preventing or … can amlodipine make you pee a lotWebPRDX1 activates autophagy via the PTEN-AKT signaling pathway to protect against cisplatin-induced spiral ganglion neuron damage. Data files. Show entries ... neurons (SGNs) are auditory neurons that relay sound signals from the inner ear to the brainstem. The ototoxic drug cisplatin can damage SGNs and thus lead to sensorineural hearing … canam lookupWebSep 15, 2024 · DESCRIPTION. Cisplatin Injection (cisplatin injection (cisplatin (cisplatin injection) injection) ) is a sterile aqueous solution, available in 50, 100 and 200 mL … canam manac groupWebApr 25, 2024 · In this study, we investigate the role of miRs and PTEN in renoprotective effect of curcumin against cisplatin-induced AKI in mice. It is aimed to reveal the mechanism of curcumin which protected the kidney and provided evidence on the therapeutic application of curcumin in alleviating AKI. Go to: Materials and methods Drugs can amlodipine raise blood sugarWebApr 5, 2013 · In addition, miR-21 induced cell survival and cisplatin resistance through downregulating the expression of phosphatase and tension homolog deleted on chromosome 10 (PTEN) and activation of Akt pathway. Inhibition of Akt using PI3K inhibitor LY 294002 could abrogate miR-21 induced cell survival. canam manac drummondville